Description
The skin is the largest organ of the human body because under a microscope it has been shown to regenerate itself on a daily basis. Its main function is to protect the human body from the outside world. Although it is a barrier, the skin is a living organ that needs nourishment. Vitamin A and its many forms are a nutrient that has been shown to improve the appearance of aging skin when applied topically*.
Cocco Clinique MD Chrono Repair PM is a pharmaceutical grade formulation that contains Retinol, a form of Vitamin A, which is one of the best long-term therapies for chronically photo aged skin*. Long term use of retinol is associated with improved skin texture, decreased sallowness, a reduction of fine rhytides (wrinkles) and actinic keratosis (pre-cancerous growths), fading of pigmented macules (freckles), and overall improvement in skin appearance.
Early side effects include redness, photosensitivity, and sloughing or desquamation until tolerance is achieved. Because skin is photosensitized, use of sunblock is absolutely imperative. Cocco Clinique MD Chrono Repair PM should be used for a minimum of 3-4 months, with the greatest improvement after 1 year of use.
Highlights:
- Anti-aging
- Collagen turnover
- Improve texture
- Diminish fine lines
- Decrease sun spots
Concerns:
- Facial aging
- Sallowness
- Fine lines and wrinkles
- Sun spots and freckles
- Actinic keratosis
Benefits:
- Anti-wrinkle
- Anti-aging
- Restorative
- Time-released
- Astringent
Mechanism of action of Retinol working at the cellular level. UV radiation activates a series of phospokinases that stimulate proto-oncogenes and thereby activate AP-1 transcription factor. AP-1 Causes activation of metalloproteases such as collagenase, gelatinase and stromelysin which break down collagen. Retinol results in a 70% inhibition of AP-1 transcription factor binding to DNA and a significant reduction in protease activity. Histologic effects include increased epidermal and granular layer thickness, elimination of dysplasia, atypic and microscopic actinic keratoses; uniform dispersion of melanin granules, increased collagen and glycosaminoglycan deposition in the papillary dermis; and diminished dermal elastosis, angiogenesis, and compaction/thinning of the stratum corneum.
Product Facts
Dosage & Administration: In the evening, apply a thin film to a freshly cleansed face, neck, décolleté, and the back of the hands. Preferably apply soon after cleansing, while the skin is still moist. Spread the cream evenly, and allow to absorb naturally. Once absorbed, follow with moisturizer only if needed. Daily application is not necessary, so use every other evening alternating with Cocco Clinique MD Vita-C. Store in a cool dry place.
Contains: Retinol, Antioxidants, Amino acids, Camellia Oleifera, Ginger Root.
Precautions: For external use only. Keep away from eyes and mucosa. If contact occurs, rinse thoroughly with water. If irritation, redness, itching or rash occurs, discontinue use and consult physician. In case of accidental ingestion, seek professional assistance or contact a poison control center immediately. Do not use if pregnant or nursing. Keep out of reach of children.
*Extreme Details: Really, this is the nitty gritty for nerds. Mechanism of action of Retinol works at the cellular level. UV radiation activates a series of phospokinases that stimulate proto-oncogenes and thereby activate AP-1 transcription factor. AP-1 Causes activation of metalloproteases such as collagenase, gelatinase and stromelysin which break down collagen. Retinol results in a 70% inhibition of AP-1 transcription factor binding to DNA and a significant reduction in protease activity. Histologic effects include increased epidermal and granular layer thickness, elimination of dysplasia, atypic and microscopic actinic keratoses; uniform dispersion of melanin granules, increased collagen and glycosaminoglycan deposition in the papillary dermis; and diminished dermal elastosis, angiogenesis, and compaction/thinning of the stratum corneum.
Disclaimer
The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition. The information on this website is not intended to diagnose, treat, cure or prevent any disease. Never disregard medical advice or delay in seeking it because of something you have read on the Cocco Clinique MD site. Product sold on this site are for personal use and not for resale. All orders placed through this website are subject to Cocco Clinique MD acceptance, in its sole discretion. This means that Cocco Clinique MD may refuse to accept, or may cancel, any order, whether or not it has been confirmed, without liability to you or any third party. Cocco Clinique MD reserves the right to discontinue any program or offer at any time.
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